E.L. Bond Sickle Cell Anemia 5 A B Figure 1. The normal red blood cell (A) is relatively round and flexible and moves easily through narrow blood vessels, while the sickle cell (B) is sickled-shaped and inflexible.1 At times the stiff, sickled cells cannot squeeze through the narrow blood vessels and stack up to block blood blogger.com Size: KB Sickle Cell Anemia Essay Words | 3 Pages. Sickle Cell Anemia Sickle cell anemia is caused by a defect in the gene that controls the production of normal hemoglobin, which is an iron-containing protein in red blood cells that transports oxygen from the lungs to body tissues May 06, · Sickle cell anemia is a disorder of the blood that is caused by the inheritance of the gene that alters the shape of the sickle cell. Therefore, the gene interferes with the working of hemoglobin in the movement of oxygen. The prevalence of the sickle cell anemia varies regarding the geographical position and the ethnic identity
Genetic Analysis Of Sickle Cell Anemia Essay - Words
This disease is a disorder of the blood brought by the inheritance of the gene that changes the shape of the sickle cell. The case provides significant insights regarding this blood disorder through examining the various issues relating to sickle cell anemia. One of the most crucial aspects towards understanding sickle cell anemia is examination of its genetic information, causes, and gene mutation.
Part 2 of the Case Report examines whether chromosomal analysis was indicated, causes of the disorder, its origin with respect to gene inheritance, sickle cell anemia essay, and gene mutation. Chromosomal Analysis Even though the case provides significant insights regarding sickle cell anemia, chromosomal analysis was not indicated. According to Quest Diagnosticschromosomal analysis is the microscopic evaluation of chromosomes in dividing cells.
The analysis is usually carried out to help in identification of changes in chromosomal structure and number. Through this processchromosomal analysis helps to detect any structural changes associated with a particular disease or condition. In this regard, the case does not indicate chromosomal analysis though it covers various aspects sickle cell anemia essay the disease. Actually, sickle cell anemia essay, the author focused on providing an overview of the causes, diagnosisand treatment of the disorder but did not indicate whether chromosomal analysis was carried out.
Causes of the Disorder One of the major issues addressed in the report is the causes of sickle cell anemia, which is considered as one of the most prevalent disorders in the modern society. In this case, sickle cell anemia is a genetic disease brought by mutated hemoglobin and hereditary in nature. The inheritance of this disorder occurs through an autosomal recessive gene with both parents. Parents with such genes are considered as asymptomatic carriers of one affected gene known as heterozygous, sickle cell anemia essay.
As a result, clinical manifestations of this condition are observed only in homozygous individuals since they inherit the detective gene from their parents. In this case, the red blood cells of a patient suffering from sickle cell anemia become rigid and sticky. The condition also affects the structure of red blood cells by shaping them These defective red blood cells can get stuck in small blood vessels and eventually block the flow of oxygen or blood to other parts of the body Mayo Staff Clinic, Origin of Sickle Cell Anemia in terms of Sickle cell anemia essay Inheritance The origin of sickle cell anemia can be attributable to single gene inheritance since the most common genotype of the disorder is homozygous sickle cell disease Serjeant, However, the single gene inheritance of sickle cell anemia occurs either homozygously or as a double heterozygote with another relating gene Serjeant, In this case, a child can inherit the defective sickle cell gene from one parent and a gene for normal hemoglobin from the other parent.
Sickle cell anemia essay, the child can inherit heterozygous gene from both parents who are asymptomatic carriers of this defective gene. The inheritance of defective genes contributes to sickle cell trait through which sickle cell anemia develops.
Given that sickle cell anemia is an inherited form of anemia, there are essential considerations for practice and patient education sickle cell anemia essay respect the single gene inheritance.
As documented in the case, sickle cell anemia essay, one of the considerations for practice is undergoing diagnosis at earlier stages of the condition. The second consideration for practice is enhancing the success of the bone marrow transplant during treatment of the disease through early diagnosis of the condition.
With regards to patient education, healthcare providers and caregivers should focus on creating awareness of the signs and symptoms of sickle cell anemia and encouraging early diagnosis. Additionally, patients should be educated on taking physician-recommended medication and ensuring drug compliance to help improve their outcomes Mayo Clinic Staff, Gene Mutation of Sickle Cell Anemia As evident in the case, sickle cell anemia is a genetic disease that is characterized by severe symptoms and relatively difficult to diagnose and treat.
This genetic disease is inherited in an autosomal recessive pattern, which implies that two copies of the gene in each cell have mutations Genetics Home Reference, Each of the parents of a person with an autosomal recessive condition carry a copy of the mutated gene, which is then passed to the child through an autosomal recessive gene.
However, parents with this gene do not usually show signs and symptoms of sickle cell anemia. This is primarily because people with one copy of the sickle cell gene do not have the condition but are more likely to pass the gene on to their sickle cell anemia essay, which contributes to a sickle cell trait in the child. Hemoglobin comprises four protein subunits that are further divided into two subunits i. alpha-globin and beta-globin. Hemoglobin protein subunit, beta-globin HBBprovides instructions for the development of beta-globin, which results in different mutations of the HBB.
Mutations in this gene i. HBB cause sickle cell anemia when they generate an abnormal version of beta-globin i. hemoglobin S HbS. On the other hand, the other mutations generate extra abnormal versions of beta-globin like hemoglobin C HbC and hemoglobin E HbE Genetics Home Reference, sickle cell anemia essay, Sickle cell anemia is developed when these HBB gene mutations result in the replacement of one beta-globin subunit with hemoglobin S.
The abnormal versions of beta-globin produced in HBB gene mutations can damage red…. References Calzone, K. Nurses Transforming Health Care Using Genetics and Genomics.
Nursing Outlook, 58 1 Genetics Home Reference. Sickle Cell Disease. Retrieved from U. The Role of Nutrition in Sickle Cell Disease. Nutrition and Metabolic Insights, 3, Lervolino, L. Prevalence of Sickle Cell Disease and Sickle Cell Trait in National Neonatal Screening Studies.
Revista Brasileira de Hematologia e Hemoterapia, 33 1 Mayo Clinic Staff. Sickle Cell Anemia. Chromosome Analysis. The Natural History of Sickle Cell Disease. Cold Spring Harbor Perspectives in Medicine, 3 For example, in the case of sickle beta thalassemia, the individual has inherited a gene for hemoglobin S. from one parent and a gene for beta-thalassemia from the other.
Or, in the instance of SC disease, the individual has inherited a gene for hemoglobin S. from one parent and a gene for hemoglobin C, sickle cell anemia essay. from the other, sickle cell anemia essay. The sickle cell trait in heterozygous carriers confers the resistance to malaria phenotype. Also, this is a relatively new procedure with a total of only people with the sickle cell disease having undergone it.
Genetic screening is one of the most controversial topics in the scientific arena today. The advent of the Human Genome Project, which maps the complete human genetic code, sickle cell anemia essay, has brought this issue to the forefront.
This paper will discuss the basic science that underlies genetic screening, applications of genetic screening, and investigate some of the common misconceptions and ethical questions about its use.
Genetic screening itself is simply "the systematic search. Considering Current Challenges As noted during the introductory chapter of this proposal, children routinely note how their parents cope with pain; their particular pain coping styles. Sickle cell anemia essay the implementation of this proposed study, this researcher expects to create a questionnaire exploring the way parents of adolescents afflicted with SCD personally handled their pain.
Program Utilizing Meta Analysis Qualitative research evaluation technique is primarily inductive. The hypothesis is developed as the study progresses so that it can capture the setting of the study. Qualitative research evaluation technique involves systematic and detailed study of population in natural setting sickle cell anemia essay is not contrived by the person conducting the study.
This technique involves the interviewer using open-ended questions intended to explore detailed accounts of the interviewee's perspectives on. In the words of Obama, "Today, with the executive order I am about to sign, we will bring the change that so many scientists and researchers, doctors and innovators, patients and loved ones have hoped for, and fought for, these past eight years: We will lift the ban on federal funding for promising embryonic stem cell research," President Obama further said.
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Sickle cell anemia - causes, symptoms, diagnosis, treatment \u0026 pathology
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Sickle cell anemia is an inherited blood disorder characterized primarily by chronic anemia and periodic episodes of pain. The underlying problem involves hemoglobin, a component of red blood cells. Hemoglobin molecules in each red blood cell carry oxygen from the lungs to body organs and tissues and bring carbon dioxide back to the lungs E.L. Bond Sickle Cell Anemia 5 A B Figure 1. The normal red blood cell (A) is relatively round and flexible and moves easily through narrow blood vessels, while the sickle cell (B) is sickled-shaped and inflexible.1 At times the stiff, sickled cells cannot squeeze through the narrow blood vessels and stack up to block blood blogger.com Size: KB As indicated by Lervolino, Baldin, Picado, Calil, Viel & Campos (), sickle cell anemia is brought by an abnormal gene, which causes a disorder to the hemoglobin. In this case, sickle cell anemia is a genetic disease brought by mutated hemoglobin and hereditary in nature. The inheritance of this disorder occurs through an autosomal recessive gene with both parents
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